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BPS BPS-Pharmacotherapy Exam Syllabus Topics:

BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A pharmacotherapy specialist is interpreting a published paper describing a randomized controlled, double-bling study that was conducted to evaluate the effects of antihistamines on the failure rate of treatment of otitis media in children. In the study, 250 children received antihistamines and 264 did not. All children received appropriate antibiotic therapy. Treatment failures occurred in four (1.6%) of the children who received antihistamines and in 13 (4.9%) of those who did not. The difference is statistically significant (p<0.05, chi-square). Which of the following statements about these result is appropriate?

A) Chi-square is not the appropriate statistical test.
B) Antihistamines should be administered to all children with otitis media who meet study entry criteria.
C) Knowledge of the rate and severity of adverse event in the study is needed to allow a therapeutic decision.
D) The sample size is inadequate to allow clinical conclusions.

2. A study is conducted comparing two antibiotics for the treatment of UTIs. The results after 7 days of therapy demonstrated that Drug A was superior to Drug B in eradicating bacteria from the urine and eliminating signs and symptoms of infections. The investigators concluded that Drug A was significantly superior to Drug B (p<0.05). In subsequent studies, however, the two drugs were equivalent in efficacy.
Which one of the following types of error apparently occurred in the first study?

A) Regression to the mean
B) Type |
C) Type ||
D) Beta error

3. A pharmacotherapy specialist wishes to investigate the impact of thiazolidinedione therapy on Weight gain. The specialist will determine average body weight immediately before participants begin therapy with pioglitazone and again after they complete 12 weeks of treatment. Which of the following statistical methods is most appropriate for analyzing these data?

A) Chi-square test
B) Fisher's exact test
C) Paired t test
D) Unpaired t test

4. A pharmacotherapy specialist is evaluating a study that compared the effects of iron sucrose versus sodium ferric gluconate on ferritin levels in patients receiving hemodialysis. A significant difference was found between the groups. This study was conducted in a large academic center in Denmark; the specialist practices at a small rural hospital in Minnesota. Which of the following information in the paper will be most important in determining whether the study's results can be applied to the specialist's practice?

A) Randomization methods
B) Statistical analysis
C) Inclusion/exclusion criteria
D) Internal validity

5. A patient in an ICU has been receiving heparin 5,000 units subcutaneously three times daily for the last 7 days. Today the patient's platelet count has dropped by more than 50%, and the patient has developed a pulmonary embolism. The patient's heparin platelet factor 4 antibody test is positive.
What is the most appropriate treatment for this patient's pulmonary embolism?

A) Dabigatran 150 mg orally twice daily
B) Warfarin 5 mg orally once daily
C) Unfractionated heparin 18 units/kg/h intravenously
D) Argatroban 2 mcg/kg/min intravenously

Solutions: