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American Society of Microbiology ABMM Sample Questions:

1. A traveler returning from a tropical region presents with fever, chills, and jaundice. Peripheral blood smear reveals the presence of ring-shaped parasites within erythrocytes. Further laboratory testing shows a positive result for Plasmodium falciparum histidine-rich protein 2 (HRP2). The MOST appropriate treatment for this patient is:

A) Metronidazole
B) Mebendazole
C) Primaquine and a blood schizonticide (e.g., artemisinin-based combination therapy)
D) Amphotericin B

2. A microbiology laboratory receives a corneal scraping from a patient with keratitis. Microscopic examination with calcofluor white stain reveals the presence of septate hyphae and conidiophores with a foot cell and phialides. The MOST likely genus is:

A) Mucor
B) Candida
C) Rhizopus
D) Aspergillus

3. A clinical microbiology laboratory is investigating a cluster of bloodstream infections caused by Staphylococcus aureus. To differentiate between community-associated (CA-MRSA) and healthcare- associated (HA-MRSA) strains, they may look for the presence of:

A) Specific staphylococcal cassette chromosome mec (SCCmec) types, such as SCCmec IV or V inCA- MRSA.
B) Panton-Valentine leukocidin (PVL) toxin genes, which are exclusively found in HA-MRSA.
C) The mecA gene, which is common to both CA-MRSA and HA-MRSA.
D) Resistance to non-beta-lactam antibiotics, which is more common in CA-MRSA.

4. A clinical microbiology laboratory is implementing a new MALDI-TOF mass spectrometry system for bacterial identification. For accurate identification, the system relies on comparing the protein profile of an unknown isolate to:

A) A database of antibiotic resistance genes.
B) A database of known bacterial ribosomal RNA sequences.
C) A database of protein mass spectra from well-characterized organisms.
D) A database of bacterial cell wall lipid compositions.

5. A patient with a history of travel to Southeast Asia presents with fever, severe headache, and altered mental status. CSF analysis reveals lymphocytic pleocytosis and elevated protein, but routine bacterial and viral cultures are negative. Serological testing of CSF is positive for IgM antibodies against Japanese encephalitis virus. The MOST likely mode of transmission for this infection is:

A) Respiratory droplets from an infected individual.
B) Ingestion of contaminated food or water.
C) Bite of an infected mosquito.
D) Direct contact with infected animals.

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